Methylcobalamin
• Active form of vitamin B12 which can directly participate in homocysteine metabolism
• Inhibit the neuropathic pain associated with diabetic neuropathy.
• Potential analgesic for nonspecific low back pain; neck pain; diabetic neuropathic pain
Alpha-lipoic acid
•reverses peripheral diabetic neuropathy through its multiple antioxidant properties.
•increases reduced glutathione, an important endogenous antioxidant
Thiamine
• benefits include energy production, support for the nervous system, heart health and antioxidant activity.
Pyridoxine
• promising adjunctive agent for improving oxidative stress and metabolic disturbances and for preventing diabetic complications including atherogenesis.
Folic acid
most important dietary determinant of homocysteine; daily supplementation with 0.5 to 5.0 mg typically lowers plasma homocysteine levels by about 25 % dose 1 tab od