Description
Each Foslift Sachet contains 3.2 g of Sodium Acid Phosphate Granules. The granules disperse when placed in water and dissolve to give a palatable solution. The solution provides elemental phosphorus 500 mg (16.1 mmol Phosphate). The sodium & potassium content in each tablet is 20.4 mmol and 3.1 mmol respectively.
PHARMACOLOGY (Biological Data) Pharmacodynamics
Phosphorus is one of the most abundant elements in the human body: nearly 85 % is present in the skeleton, with the balance in soft tissues and extracellular fluid. Most phosphorus is complexed as phosphate which is the body’s major intracellular anion and an essential component of cell membrane phospholipids, DNA, and RNA. It is also critical to most biochemical processes, including ATP synthesis and metabolic and enzymatic pathways. Phosphorus, as phosphate, also assists in maintaining normal physiological pH balance.
Phosphorus balance is regulated by several hormones, including Parathyroid hormone (PTH), which controls the release of phosphate from bones and inhibits renal reabsorption. Serum phosphate levels are inversely proportional to serum calcium levels and their physiological requirements are the same.
Mechanism of Action
Oral administration of inorganic phosphates produces a fall in serum calcium in patients with hypercalcemia. The sodium ions in Foslift granules aid in the correction of the dehydration and sodium depletion which is seen in hypercalcemia. In cases of hypercalcemia associated with impaired renal function and hypophosphatemia, the main effect of oral phosphate is to bind calcium in the gut and thus reduce calcium absorption.
Pharmacokinetics Absorption & Distribution
Phosphates are mainly absorbed from the jejunum and duodenum by passive and active transport. Approximately two thirds of ingested phosphate is absorbed from the gastrointestinal tract and most absorbed phosphate is filtered by the glomeruli and subsequently undergoes reabsorption. PTH and Vitamin D stimulate absorption of phosphate from the small intestine and its reabsorption from the proximal tubule.
Metabolism & Excretion
Virtually all absorbed phosphate is excreted in the urine; the remainder being excreted in the faeces.
Foslift Granules are used as an oral phosphate supplement in the treatment of the following conditions:
1. Hypophosphatemia
2. Hypercalcemia
3. Phosphate Depletion
4. Calcium Based Kidney Stone
Foslift Granules sachet should be emptied & dissolved in 2/3rd to 1 full glass of water. The dosage should be adjusted to suit the requirements of individual patients.
- Phosphate depletion: Up to 3 g/d in 3 to 4 divided doses
- Hypophosphatemia: 2-3 g/d in 3 to 4 divided doses
- Hypercalcemia : 1-2 g/d
- Calcium based Kidney Stone: 1-2 g/d
For a patient weighing
|
60 Kg |
15 mmol every 6 hours with meals |
1 sachet of Foslift qid |
|
70 Kg |
17.5 mmol every 6 hours with meals |
1 sachet of Foslift qid |
|
100 Kg |
25 mmol every 6 hours with meals |
1.5 sachet of Foslift qid |
As per guidelines, phosphorus level will increase by an average of 1.2 mg/dl with a dose of 0.25 mmol/ kg
Each Foslift Sachet contains 3.2 g of sunset yellow colour Sodium Acid Phosphate Granules. Each pack contains 15 sachets of Foslift Granules.
Store the medicine in a cool, dry place between 15 to 30 degrees Celsius. Protect from sunlight.
